Alendronate in Periodontics: An Evolving Trend

Periodontitis is an immunoinflammatory disease that causes destruction of tooth supporting tissues. It is characterized by mulifactorial etiology involving bacterial biofilm and an inflammatory host response. The inflammatory ho destruction; thus novel therapeutic modalities should be considered that modulates host response. The proven efficacy of bisphosphonates to inhibit osteoclast bone resorption has led to their us modulating agent in the persepective of preventing the alveolar bone loss. Bisphosphonates were also proposed to have osteostimulative properties in vivo; thus can be used with bone regenerative materials to potentiate bone regeneration This use of novel aminobisphosphonate alendronate in periodontal therapy.